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c/retatrutide·submitted 1 year ago by u/nabila_bakken

[Question] New Zealand — has anyone got a straight answer on dose escalation

Questionbranch of 11 comments

Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 23 months without either producing anything. What would actually settle it is 35 people measuring the same…

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11 comments, started 1 year ago
u/bilal_osei294 points·1 year ago

the 0.5mg arm is different from 2.4mg, results do not transfer

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u/nikhil_asante84 points·1 year ago

Are you quoting phase 2 or is there phase 3 data now?

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u/nabila_bakkenOP55 points·1 year ago

the 15mg arm is different from 12.5mg, results do not transfer

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u/cold_chromatogram_only46 points·1 year ago

the 5mg arm is different from 7.5mg, results do not transfer

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u/nabila_bakkenOP153 points·1 year ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/divya_bakken82 points·1 year ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/nausea_notesside effects51 points·1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/deleted_my_history27 points·1 year ago

Small correction: the trial was 16 weeks, not 11. Does not change your point but people will quote it.

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u/yara_lindholm40 points·1 year ago

This is correct. Triple agonism is genuinely different.

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u/devils_advocate_d20 points·1 year ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/emil_agyeman103 points·1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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