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c/retatrutide·submitted 1 months ago by u/hassan_nilsen

the phase 2 question that gets asked weekly, answered properly

Cautionbranch of 10 comments

Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything. What would actually settle it is 39 people measuring the same…

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This branch

10 comments, started 28 days ago
u/aa_analysis_andy106 points·28 days ago

triple agonism is phase 2, do not generalise

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u/honest_syringe_2025-35 points·28 days ago

What was the dosing schedule in that arm?

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u/kofi_balogun88 points·28 days ago

You have restated the marketing copy. What is the actual substance here.

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u/nikhil_lindqvist59 points·28 days ago

Are you quoting phase 2 or is there phase 3 data now?

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u/kavya_kravchenko22 points·28 days ago

triple agonism is phase 2, do not generalise

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u/cagrilintide_enthusiast47 points·28 days ago

You have restated the marketing copy.

Yes, exactly this, and it is the bit that took me 88 weeks to accept.

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u/vito_beaulieu36 points·28 days ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/devils_advocate_d29 points·28 days ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/cagrilintide_enthusiast38 points·28 days ago

the 2.5mg arm is different from 2.4mg, results do not transfer

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u/yusuf_ramos21 points·28 days ago

I am going to push back on this slightly.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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