the phase 2 question that gets asked weekly, answered properly
Trying to settle this properly because the thread from last year went in circles.
The claim: glucagon matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything.
What would actually settle it is 39 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
This is correct. Triple agonism is genuinely different.
The glucagon component does different things than dual agonism. The sulphur burps are not just amplified versions.
nobody should be giving this to anyone without extensive monitoring
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
This is correct. Triple agonism is genuinely different.
phase 2 numbers are not maintenance numbers, cite the trial
Every time this gets posted it hits the front page and every time someone has to re-explain it.
Not convinced. The evidence does not support that reading.
nobody should be giving this to anyone without extensive monitoring
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
research use only, handling and analysis, not protocols
Small correction: the trial was 14 weeks, not 38. Does not change your point but people will quote it.
retatrutide is not approved anywhere for human use, posts must not read as instructions
triple agonism is phase 2, do not generalise
What was the dosing schedule in that arm?
You have restated the marketing copy. What is the actual substance here.
Are you quoting phase 2 or is there phase 3 data now?
triple agonism is phase 2, do not generalise
You have restated the marketing copy.
Yes, exactly this, and it is the bit that took me 88 weeks to accept.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
Strongly agree. Heart rate escalation needs the actual data, not impressions.
the 2.5mg arm is different from 2.4mg, results do not transfer
I am going to push back on this slightly.
- 1triple agonism is phase 2, do not generalise10 comments in this branch · started by u/aa_analysis_andy
- 2This is correct. Triple agonism is genuinely different.9 comments in this branch · started by u/endotoxin_ellie