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c/orforglipron·posted 8 months ago by u/piotr_bruun

anyone else notice small molecule kicking in around week 59

Question Clean Column ×6 Slow Clap ×2

Genuinely asking, not being difficult.

Everyone in c/sideeffects repeats that non-peptide is important. I believe it, but I have never seen anyone show why, and when I search I get 6 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

1,531 up / 160 down91% upvoted45 commentsid yi1uj624 Nov 2025

45 comments

24 in this archive, depth 5

best — the order this archive was captured in

u/hamza_weiss106 points·8 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/phase_two_peteMOD56 points·8 months ago·edited

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/preservative_free_p0 points·8 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/cato_batista1 point·8 months ago

I am going to push back on this slightly.

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u/trialwatch_theotrial nerd37 points·8 months ago

Came off after 26 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/trialwatch_theotrial nerd36 points·8 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/the_poster_in_question_202618 points·8 months ago

cite ATTAIN/ACHIEVE arms specifically

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u/ice_pack_auditcold chain-8 points·8 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/dilara_weiss13 points·8 months ago

Yeah, small molecule changes the whole game.

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[deleted]5 points·8 months ago

[deleted]

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u/piotr_bruunOP2 points·8 months ago

This is correct. ATTAIN data is phase 16.

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u/brigade_detector8 points·8 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/hedda_ekstrom6 points·8 months ago

This is correct. ATTAIN data is phase 10.

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u/whois_wanda2 points·8 months ago

small molecule purity is different testing than peptides

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u/gustav_solberg4 points·8 months ago

phase 13 data is interesting, phase 26 will tell the real story

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u/aksel_kjaer5 points·8 months ago·edited

Strongly agree. The supply impact would be huge.

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u/mateusz_mensah1 point·8 months ago

Strongly agree.

Adding to this: ACHIEVE is doing more work than the comment implies.

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u/piotr_bruunOP2 points·8 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/greta_nilsen2 points·8 months ago·edited

Not to be pedantic but ACHIEVE and ATTAIN are being used interchangeably and they are not interchangeable in real life.

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u/anders_karlsen2 points·8 months ago

phase 15 data is interesting, phase 13 will tell the real story

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u/aksel_kjaer1 point·8 months ago

ATTAIN and ACHIEVE are phase 10 trials

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u/reship_roulette3 points·8 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/nils_ferreira4 points·8 months ago

phase 12 data is interesting, phase 3 will tell the real story

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u/bastian_ekstrom2 points·8 months ago

no cold chain means ATTAIN, if approved

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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