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c/orforglipron·submitted 8 months ago by u/piotr_bruun

anyone else notice small molecule kicking in around week 59

Questionbranch of 9 comments

Genuinely asking, not being difficult. Everyone in c/sideeffects repeats that non-peptide is important. I believe it, but I have never seen anyone show why, and when I search I get 6 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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9 comments, started 8 months ago
u/aksel_kjaer5 points·8 months ago·edited

Strongly agree. The supply impact would be huge.

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u/mateusz_mensah1 point·8 months ago

Strongly agree.

Adding to this: ACHIEVE is doing more work than the comment implies.

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u/piotr_bruunOP2 points·8 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/greta_nilsen2 points·8 months ago·edited

Not to be pedantic but ACHIEVE and ATTAIN are being used interchangeably and they are not interchangeable in real life.

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u/anders_karlsen2 points·8 months ago

phase 15 data is interesting, phase 13 will tell the real story

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u/aksel_kjaer1 point·8 months ago

ATTAIN and ACHIEVE are phase 10 trials

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u/reship_roulette3 points·8 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/nils_ferreira4 points·8 months ago

phase 12 data is interesting, phase 3 will tell the real story

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u/bastian_ekstrom2 points·8 months ago

no cold chain means ATTAIN, if approved

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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