lowest effective dose — 4 things I got wrong before I got it right
Genuinely asking, not being difficult.
Everyone in c/trialwatch repeats that goal weight is important. I believe it, but I have never seen anyone show why, and when I search I get 9 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
regain is not a moral failing
Did you stretch the dose interval?
weight moves within 20kg and that is normal
the plateau is where the learning happens
dose-stretching experiences welcome, dose-stretching instructions are not
regain is not a moral failing
Disagree on that part. 97.9% and 97.6% on the same vial is normal.
regain is not a moral failing Disagree on that part.
Yes, exactly this, and it is the bit that took me 45 weeks to accept.
[removed by moderator]
the maintenance question changes at maintenance
regain after taper is expected, plan for it
Retitled to remove editorialising. Put the evidence in the body.
This is the "correlation is mechanism" thing again. You changed three variables at once.
the regain question changes at maintenance
the 12.5mg dose works fine for 10 weeks of the month
The plateau is real and boring. 28 weeks at the same weight, then movement again. Patience was the intervention.
the plateau is where the learning happens
Small correction: the trial was 21 weeks, not 20. Does not change your point but people will quote it.
Strongly agree. Lowest effective dose is a real discovery process.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
state how long you have been at maintenance, week 13 is not maintenance
the lowest dose you can stay on is not the lowest dose that works
Yeah, maintenance is the boring part and the important part.
weight moves within 3kg and that is normal
Regain on a taper is expected. 6% back over 12 weeks, which matches the discontinuation data. Planned for it.
Yeah, maintenance is the boring part and the important part.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
dose-stretching experiences welcome, dose-stretching instructions are not
the lowest dose you can stay on is not the lowest dose that works
Yeah, maintenance is the boring part and the important part.
- 1regain is not a moral failing10 comments in this branch · started by u/brigade_detector
- 2The plateau is real and boring. 28 weeks at the same weight, then movement…10 comments in this branch · started by u/noor_cardoso