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c/glp1women·posted 1 year ago by u/pavel_nkemelu

[Discussion] insulin resistance is doing more work than we give it credit for

Discussion Cold Box ×5 The Quiet One ×3

Week 39 update. 10kg down from the start, early fullness basically gone since about week 79.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

1,827 up / 355 down84% upvoted41 commentsid 2qjk7n15 Nov 2024

41 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/reads_the_wiki207 points·1 year ago

I am going to push back on this slightly.

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u/gentle_correctionMOD160 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/ewan_zielinski77 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/karl_fischer_kev22 points·1 year ago

Sceptical.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/nnt_nate39 points·1 year ago

fertility signal is there but unclear

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u/mei_cardoso122 points·1 year ago

Removed a chain here.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/emil_marchand76 points·1 year ago

fertility signal is there but unclear

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u/low_appetite_lisa56 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

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u/joaquin_trevino87 points·1 year ago

the cycle question is under-powered in trials

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u/pavel_nkemeluOP57 points·1 year ago·edited

Maintenance for 14 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/emeka_chowdhury28 points·1 year ago

the cycle tracking data matters, keep it private

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u/lipid_panel_larrybloodwork71 points·1 year ago

This is correct. PCOS is real.

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u/jonas_cardoso25 points·1 year ago

This is correct.

Yes, exactly this, and it is the bit that took me 56 weeks to accept.

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[deleted]32 points·1 year ago

[deleted]

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u/viktor_laurent45 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/micro_bump_mick12 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/idris_kimani32 points·1 year ago

hormonal contraception interactions are speculative

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u/zaid_grimaldi15 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

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u/tared_twice21 points·1 year ago

hormonal contraception interactions are speculative

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u/enzo_fonseca17 points·1 year ago

fertility signal is there but unclear

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u/karl_fischer_kev0 points·1 year ago

the cycle question is under-powered in trials

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u/gustav_lindholm1 point·1 year ago

I am going to push back on this slightly.

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u/karl_fischer_kev1 point·1 year ago

cycle changes are real and under-researched

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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