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c/glp1women·posted 3 months ago by u/vito_beaulieu

help me understand cycle, I have read the wiki twice

PCOS

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking PCOS against ApoB for 37 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

81 up / 3 down97% upvoted13 commentsid 1mhzxs18 Apr 2026

13 comments

13 in this archive, depth 4

best — the order this archive was captured in

u/sanne_novak15 points·3 months ago
the VendorInvestigate number or it did not happen
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u/gustav_lindholm10 points·3 months ago

the cycle question is under-powered in trials

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[removed]7 points·3 months ago

[removed by moderator]

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u/viktor_erdogan3 points·3 months ago

Yeah, insulin resistance is under-researched.

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u/rina_sobczak-9 points·3 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/sanne_novak1 point·3 months ago

pregnancy and trying-to-conceive get clinician pointer, not community advice

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u/ines_boateng1 point·3 months ago

PCOS and insulin resistance

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u/jonas_cardoso4 points·3 months ago

Mechanistically the bit that matters is fertility. It explains most of the early profile and a decent chunk of the outcome.

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u/pavel_kravchenko2 points·3 months ago

Mechanistically the bit that matters is fertility.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/dilara_szabo1 point·3 months ago

the trials mostly studied men, insulin resistance skipped

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u/ferran_laurent1 point·3 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/zeynep_weiss0 points·3 months ago

PCOS and insulin resistance

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u/nils_tulloch3 points·3 months ago·edited

Sweden here. Waited 9 months on a list, gave up, went private, and the total cost was roughly what I expected.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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