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c/glp1women·posted 2 months ago by u/katrin_diallo

[Results] 7 weeks, 40kg, and contraception was the hard part

Results

Genuinely asking, not being difficult.

Everyone in c/darkspot repeats that insulin resistance is important. I believe it, but I have never seen anyone show why, and when I search I get 13 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

294 up / 112 down72% upvoted18 commentsid 16yj4628 May 2026

18 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/emil_marchand-36 points·2 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/katrin_dialloOP1 point·2 months ago

The the food-noise thing was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/zaid_roos1 point·2 months ago·edited

hormonal contraception interactions are speculative

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u/elin_lindqvist1 point·2 months ago

Which country? Half the answers in this thread only apply in France.

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u/ilias_kaufmann1 point·2 months ago

Strongly agree. Cycle changes are documented.

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u/jarno_karlsen1 point·2 months ago

I am going to push back on this slightly.

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u/anders_karlsen-46 points·2 months ago

Not convinced. The evidence does not support that reading.

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u/milan_wikstrom21 points·2 months ago

Strongly agree. Cycle changes are documented.

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u/cesar_oyelaran26 points·2 months ago

Slight fix: the number was 97.6, not 97.4. Decimal point, but a fairly consequential one.

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u/step_therapy_s30 points·2 months ago

Slight fix: the number was 97.6, not 97.4.

Yes, exactly this, and it is the bit that took me 10 weeks to accept.

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u/sterile_field_steph8 points·2 months ago

contraception interaction claims need citation

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u/blunt_coldbox2918 points·2 months ago

This is correct. PCOS is real.

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u/bastian_aalto14 points·2 months ago

This is correct.

Disagree on that part. 98.1% and 98.9% on the same vial is normal.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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