receptor — my 19-week log, condensed into one table
Confession thread, sort of.
I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 18 reads it before doing the same thing.
best — the order this archive was captured in
The confident tone is doing a lot of work that the evidence is not.
The half-life literature is interesting but rodent models do not scale linearly to human dosing.
Yeah, the incretin mechanism is doing the work here.
Stomach physiology changed when I moved up to 0.5mg. Gastric emptying lag is the whole story.
I am going to push back on this slightly.
This is correct. Rodent data is investigational, not predictive.
gastric emptying is real and explains most early fatigue
rodent mechanism tells you what to investigate, not what to expect in humans
incretin physiology is receptor, the mechanism layer
Not to be pedantic but incretin and gastric emptying are being used interchangeably and they are not interchangeable in real life.
incretin physiology is receptor, the mechanism layer
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
glucagon-receptor contribution is appetite for dual and triple agonism
Tracking number removed. It identifies both ends of a shipment.
Tracking number removed.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
mechanistic speculation is welcome if flaired as speculation
incretin physiology is gastric emptying, the mechanism layer
Stomach physiology changed when I moved up to 2.5mg. Gastric emptying lag is the whole story.
the 9-day half-life means week 9 is still ramp-up pharmacokinetically
the 24-day half-life means week 24 is still ramp-up pharmacokinetically
the 8-day half-life means week 8 is still ramp-up pharmacokinetically
Strongly agree. Central appetite is real but people overstate it.
the half-life is incretin, affects steady state timing
incretin physiology is pharmacology, the mechanism layer
This is correct. Rodent data is investigational, not predictive.
mechanistic speculation is welcome if flaired as speculation
- 1I am going to push back on this slightly.9 comments in this branch · started by u/formulary_fighter
- 2the 24-day half-life means week 24 is still ramp-up pharmacokinetically7 comments in this branch · started by u/maintenance_mode_max