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c/glp1science·submitted 3 months ago by u/yusuf_ramos

receptor — my 19-week log, condensed into one table

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Confession thread, sort of. I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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7 comments, started 2 months ago
u/maintenance_mode_maxmaintenance108 points·2 months ago

the 24-day half-life means week 24 is still ramp-up pharmacokinetically

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u/annika_fonseca37 points·2 months ago

the 8-day half-life means week 8 is still ramp-up pharmacokinetically

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u/neha_krastev22 points·2 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/employer_carveout86 points·2 months ago·edited

the half-life is incretin, affects steady state timing

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u/brigade_detector70 points·2 months ago

incretin physiology is pharmacology, the mechanism layer

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u/trialwatch_theotrial nerd54 points·2 months ago·edited

This is correct. Rodent data is investigational, not predictive.

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u/saskia_lokken18 points·2 months ago·edited

mechanistic speculation is welcome if flaired as speculation

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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