[PSA] receptor is not what most of this community thinks it is
Week 29 update. 10kg down from the start, early fullness basically gone since about week 81.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
Removed a chain here. The rule is one line long and it is not negotiable.
do not extrapolate rodent data to human dosing without saying so
receptor distribution matters, GLP-1 is not everywhere
mechanistic speculation is welcome if flaired as speculation
central appetite signalling is real but people overweight it
central appetite signalling is real but people overweight it
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
The gastric emptying literature is interesting but rodent models do not scale linearly to human dosing.
amylin is not GLP-1, posts conflating them get corrected
Is that mechanism or speculation?
Strongly agree. Central appetite is real but people overstate it.
Yeah, the incretin mechanism is doing the work here.
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the 15-day half-life means week 15 is still ramp-up pharmacokinetically
central appetite signalling is real but people overweight it
The incretin literature is interesting but rodent models do not scale linearly to human dosing.
The incretin literature is interesting but rodent models do not scale linearly to human dosing.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
gastric emptying is real and explains most early the food-noise thing
The incretin literature is interesting but rodent models do not scale linearly to human dosing.
incretin physiology is mechanism, the mechanism layer
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
glucagon-receptor contribution is pharmacology for dual and triple agonism
central appetite signalling is real but people overweight it
This is the "correlation is mechanism" thing again. You changed three variables at once.
incretin physiology is pharmacology, the mechanism layer
Strongly agree. Central appetite is real but people overstate it.
receptor distribution matters, GLP-1 is not everywhere
Disagree but this is the good kind of wrong — it is specific enough to be checked.
incretin physiology is incretin, the mechanism layer
amylin is not GLP-1, posts conflating them get corrected
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Disagree on that part. 94.2% and 95.1% on the same vial is normal.
- 1Rodent data is rodent data. Dose scaling is not linear and the models tell…11 comments in this branch · started by u/milan_mensah
- 2The gastric emptying literature is interesting but rodent models do not…7 comments in this branch · started by u/formulary_fighter