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c/glp1science·submitted 8 months ago by u/marisol_kravchenko

[PSA] receptor is not what most of this community thinks it is

Speculationbranch of 7 comments

Week 29 update. 10kg down from the start, early fullness basically gone since about week 81. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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7 comments, started 8 months ago
u/formulary_fighterappeals48 points·8 months ago

The gastric emptying literature is interesting but rodent models do not scale linearly to human dosing.

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u/hassan_castellanos21 points·8 months ago·edited

amylin is not GLP-1, posts conflating them get corrected

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u/rasmus_kimani29 points·8 months ago

Is that mechanism or speculation?

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u/greta_lokken9 points·8 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/priya_guerrero22 points·8 months ago

Yeah, the incretin mechanism is doing the work here.

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[removed]8 points·8 months ago

[removed by moderator]

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u/milos_vanhecke7 points·8 months ago

the 15-day half-life means week 15 is still ramp-up pharmacokinetically

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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