[PSA] receptor is not what most of this community thinks it is
Week 29 update. 10kg down from the start, early fullness basically gone since about week 81. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
glucagon-receptor contribution is pharmacology for dual and triple agonism
central appetite signalling is real but people overweight it
This is the "correlation is mechanism" thing again. You changed three variables at once.
incretin physiology is pharmacology, the mechanism layer
Strongly agree. Central appetite is real but people overstate it.
receptor distribution matters, GLP-1 is not everywhere
Disagree but this is the good kind of wrong — it is specific enough to be checked.
incretin physiology is incretin, the mechanism layer
amylin is not GLP-1, posts conflating them get corrected
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Disagree on that part. 94.2% and 95.1% on the same vial is normal.