the half-life question that gets asked weekly, answered properly
Week 41 update. 37kg down from the start, early fullness basically gone since about week 93.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
Retitled to remove editorialising. Put the evidence in the body.
Yeah, the incretin mechanism is doing the work here.
Yeah, the incretin mechanism is doing the work here.
Disagree on that part. 98.4% and 98.3% on the same vial is normal.
central appetite signalling is real but people overweight it
Respectfully this is a sample of one presented as a finding.
the 7-day half-life means week 7 is still ramp-up pharmacokinetically
Dead space in the needle hub holds a small but non-trivial volume.
Adding to this: gastric emptying is doing more work than the comment implies.
gastric emptying is real and explains most early nausea
Yeah, the incretin mechanism is doing the work here.
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
the half-life is incretin, affects steady state timing
the 4-day half-life means week 4 is still ramp-up pharmacokinetically
the half-life is incretin, affects steady state timing
Disagree on that part. 98.7% and 98.3% on the same vial is normal.
Rodent, human, or in vitro?
Stomach physiology changed when I moved up to 0.25mg. Gastric emptying lag is the whole story.
glucagon-receptor contribution is appetite for dual and triple agonism
You have restated the marketing copy. What is the actual substance here.
glucagon-receptor contribution is incretin for dual and triple agonism
gastric emptying is real and explains most early nausea
Strongly agree. Central appetite is real but people overstate it.
do not extrapolate rodent data to human dosing without saying so
Small correction: the trial was 16 weeks, not 16. Does not change your point but people will quote it.
Where does the receptor data actually come from?
amylin is not GLP-1, posts conflating them get corrected
amylin is not GLP-1, posts conflating them get corrected
amylin is not GLP-1, posts conflating them get corrected
Adding to this: appetite is doing more work than the comment implies.
- 1Dead space in the needle hub holds a small but non-trivial volume. On…11 comments in this branch · started by u/nadia_fonseca
- 2oh thank god it is not just me10 comments in this branch · started by u/analog_alphabet