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Single comment threadYou are looking at one branch of the half-life question that gets asked weekly, answered properly — 38 comments in the full submission. View in context.
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c/glp1science·submitted 5 months ago by u/aleksi_eriksen

the half-life question that gets asked weekly, answered properly

Discussionbranch of 10 comments

Week 41 update. 37kg down from the start, early fullness basically gone since about week 93. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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10 comments, started 5 months ago
u/analog_alphabet187 points·5 months ago
oh thank god it is not just me
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u/wholesome_lurker275 points·5 months ago

glucagon-receptor contribution is appetite for dual and triple agonism

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u/tomas_lundgren0 points·5 months ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/brigade_detector1 point·5 months ago

glucagon-receptor contribution is incretin for dual and triple agonism

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u/aleksi_eriksenOP1 point·5 months ago

gastric emptying is real and explains most early nausea

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u/bastian_ekstrom113 points·5 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/ingrid_correia54 points·5 months ago

do not extrapolate rodent data to human dosing without saying so

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u/enzo_danquah39 points·5 months ago

Small correction: the trial was 16 weeks, not 16. Does not change your point but people will quote it.

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u/tomas_lundgren27 points·5 months ago

Where does the receptor data actually come from?

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u/emeka_chowdhury22 points·5 months ago

amylin is not GLP-1, posts conflating them get corrected

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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