[Question] gastric emptying — what am I missing here
Week 19 update. 25kg down from the start, reflux basically gone since about week 59.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
Respectfully this is a sample of one presented as a finding.
Which paper are you quoting?
the half-life is receptor, affects steady state timing
the 14-day half-life means week 14 is still ramp-up pharmacokinetically
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Yeah, the incretin mechanism is doing the work here.
the 15-day half-life means week 15 is still ramp-up pharmacokinetically
rodent mechanism tells you what to investigate, not what to expect in humans
This is correct. Rodent data is investigational, not predictive.
Strongly agree. Central appetite is real but people overstate it.
gastric emptying is real and explains most early muscle cramps
Strongly agree. Central appetite is real but people overstate it.
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
mechanistic speculation is welcome if flaired as speculation
central appetite signalling is real but people overweight it
mechanistic speculation is welcome if flaired as speculation
Stomach physiology changed when I moved up to 10mg. Gastric emptying lag is the whole story.
The confident tone is doing a lot of work that the evidence is not.
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
This is correct. Rodent data is investigational, not predictive.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
This is the "correlation is mechanism" thing again. You changed three variables at once.
the 11-day half-life means week 11 is still ramp-up pharmacokinetically
The half-life is 6 hours, which means week 6 is genuinely still ramp-up. Week 37 is steady state.
Where does the gastric emptying data actually come from?
amylin is not GLP-1, posts conflating them get corrected
rodent receptor tells you what to investigate, not what to expect in humans
rodent half-life tells you what to investigate, not what to expect in humans
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