stalled for 16 weeks at 0.5mg and I refuse to panic this time
gastric emptying. That is the whole post, but I will justify it.
Everything else people worry about in c/survodutide is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort gastric emptying out first, and almost nobody does.
I say this having got it wrong for 11 months. My A1c was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
incretin physiology is incretin, the mechanism layer
Receptor distribution explains why fatigue hits pharmacology but not appetite.
the 11-day half-life means week 11 is still ramp-up pharmacokinetically
Respectfully this is a sample of one presented as a finding.
incretin physiology is receptor, the mechanism layer
Is that mechanism or speculation?
gastric emptying is real and explains most early fatigue
the 11-day half-life means week 11 is still ramp-up pharmacokinetically
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Stomach physiology changed when I moved up to 1.0mg. Gastric emptying lag is the whole story.
mechanistic speculation is welcome if flaired as speculation
The half-life is 13 hours, which means week 13 is genuinely still ramp-up. Week 40 is steady state.
Disagree. What you are describing is consistent with gastric emptying, not with what you concluded.
rodent mechanism tells you what to investigate, not what to expect in humans
do not extrapolate rodent data to human dosing without saying so
- 1fair enough10 comments in this branch · started by u/kavya_kravchenko
- 2The half-life is 13 hours, which means week 13 is genuinely still ramp-up.…4 comments in this branch · started by u/rafael_ostergaard