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Single comment threadYou are looking at one branch of stalled for 16 weeks at 0.5mg and I refuse to panic this time — 18 comments in the full submission. View in context.
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c/glp1science·submitted 7 months ago by u/the_poster_in_question_2026

stalled for 16 weeks at 0.5mg and I refuse to panic this time

Paperbranch of 10 comments

gastric emptying. That is the whole post, but I will justify it. Everything else people worry about in c/survodutide is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort gastric emptying out first, and almost nobody does. I say this having got it wrong for…

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10 comments, started 7 months ago
u/kavya_kravchenko-13 points·7 months ago
fair enough
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u/saskia_lokken1 point·7 months ago

the 11-day half-life means week 11 is still ramp-up pharmacokinetically

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u/laila_almeida1 point·7 months ago

Respectfully this is a sample of one presented as a finding.

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u/sig_figs_sammod · analytical1 point·7 months ago

incretin physiology is receptor, the mechanism layer

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u/tomas_broberg1 point·7 months ago

Is that mechanism or speculation?

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u/the_poster_in_question_2026OP0 points·7 months ago

gastric emptying is real and explains most early fatigue

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u/bastian_eriksen1 point·7 months ago

the 11-day half-life means week 11 is still ramp-up pharmacokinetically

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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[deleted]1 point·7 months ago

[deleted]

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u/the_poster_in_question_2026OP1 point·7 months ago

Stomach physiology changed when I moved up to 1.0mg. Gastric emptying lag is the whole story.

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u/rohan_steiner1 point·7 months ago

mechanistic speculation is welcome if flaired as speculation

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