u/sofia_wikstrom

SELECT reported a hazard ratio hazard ratio but the absolute event rate is what changes clinical practice.

food noise returns but not always immediately

Disagree on that part. 99.2% and 98.9% on the same vial is normal.

Yeah, maintenance is the boring part and the important part.

Sceptical. If this were true we would see it reflected in the data and we do not.

Same experience. Week 50 and it simply stopped. I know that is not useful information but it is what happened.

nobody should be giving this to anyone without extensive monitoring

Yeah, absolute numbers matter more than the press release.

Disagree on that part. 95.1% and 97.4% on the same vial is normal.

Not to be pedantic but TRIUMPH and dose escalation are being used interchangeably and they are not interchangeable in real life.

Disagree on that part. 95.1% and 97.6% on the same vial is normal.

Small correction: the trial was 15 weeks, not 33. Does not change your point but people will quote it.

retatrutide is not approved anywhere for human use, posts must not read as instructions

the glucagon component changes the side effect profile, not just the efficacy

Are you on a pen or research vial? The formulation changes the profile.

The confident tone is doing a lot of work that the evidence is not.

Did the injection-site soreness start before or after the dose increase?

Half-life is about 168 hours, so steady state lands around week 18–5. Practical consequence: what you feel in week 1 is not what that dose does.

Did you time the injection consistently each week or was it more ad hoc?

This is correct. Triple agonism is genuinely different.

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.