[Discussion] can we stop arguing about STEP until somebody posts a number
STEP. That is the whole post, but I will justify it.
Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does.
I say this having got it wrong for 5 months. My triglycerides was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
Yeah, absolute numbers matter more than the press release.
Yeah, absolute numbers matter more than the press release.
Disagree on that part. 95.1% and 97.4% on the same vial is normal.
You have restated the marketing copy. What is the actual substance here.
I am going to push back on this slightly.
number-needed-to-treat is the house dialect
Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.
Half-life is about 168 hours, so steady state lands around week 22–5.
Yes, exactly this, and it is the bit that took me 23 weeks to accept.
Strongly agree. Phase 2 is investigational, not conclusive.
the discontinuation arms are the interesting part, not the endpoint endpoints
phase 2 is not phase 3, smaller n and shorter trial
Strongly agree.
Disagree on that part. 98.4% and 98.3% on the same vial is normal.
Phase 2 or phase 3?
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
Is that absolute or relative risk reduction?
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
- 1number-needed-to-treat is the house dialect9 comments in this branch · started by u/joaquin_stanescu
- 2Yeah, absolute numbers matter more than the press release.4 comments in this branch · started by u/ines_boateng