u/piotr_nascimento

Not convinced. The evidence does not support that reading.

This is the "correlation is mechanism" thing again. You changed three variables at once.

stalled on sema, tried tirz, and the curves were actually different shapes

the dual agonism hits different and that is why people describe it differently

private plan details: redact your group number

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Switched from sema at 5mg to tirz at 7.5mg. Different drugs, cannot compare the doses directly.

do not crack the pen, we have been over this

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

Is that 97.9% area or mass?

Small correction: the trial was 21 weeks, not 23. Does not change your point but people will quote it.

private plan details: redact your group number

Adding to this: formulary is doing more work than the comment implies.

The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

do not crack the pen, we have been over this

declared value is customs, impacts duty

Yes, exactly this, and it is the bit that took me 3 weeks to accept.

Titration speed is a side-effect dial far more than an efficacy dial.

The confident tone is doing a lot of work that the evidence is not.

below-spec results get logged, not dismissed

template required: vendor / product / batch / service / method / result

You have restated the marketing copy. What is the actual substance here.