week 71 check-in — 17kg down, fatigue manageable, one thing confusing me
Been lurking in c/orforglipron for about 10 months and finally have something worth posting.
Short version: week 96, 12.5mg, and dual agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 35 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 7.
best — the order this archive was captured in
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
You have restated the marketing copy. What is the actual substance here.
This is the "correlation is mechanism" thing again. You changed three variables at once.
dual agonism is SURPASS, do not generalise from semaglutide
Switched from sema at 7.5mg to tirz at 15mg. Different drugs, cannot compare the doses directly.
the appetite change on tirz is more than just reduced hunger, it is different machinery
the dual agonism hits different and that is why people describe it differently
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Week 35 on Mounjaro and 11kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
the dual agonism hits different and that is why people describe it differently
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Small correction: the trial was 24 weeks, not 39. Does not change your point but people will quote it.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
How long at each step before you escalated?
SURMOUNT data is messier than STEP data but the weight loss is there
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
- 1This is the "correlation is mechanism" thing again. You changed three…9 comments in this branch · started by u/elin_varga
- 2Water content matters more than people think. If a vial is carrying residual…6 comments in this branch · started by u/ignacio_vanhecke