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c/tirzepatide·submitted 1 year ago by u/piotr_nascimento

week 71 check-in — 17kg down, fatigue manageable, one thing confusing me

Resultsbranch of 6 comments

Been lurking in c/orforglipron for about 10 months and finally have something worth posting. Short version: week 96, 12.5mg, and dual agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 35 threads, and the answers split roughly down the middle. What I actually want…

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6 comments, started 1 year ago
u/ignacio_vanhecke142 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/hub_opssite staff0 points·1 year ago

Small correction: the trial was 24 weeks, not 39. Does not change your point but people will quote it.

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u/swirl_dont_shakereconstitution1 point·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/rania_diallo1 point·1 year ago

How long at each step before you escalated?

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u/alcohol_aversion1 point·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/aksel_kjaer-11 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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