SURMOUNT vs SURPASS — genuinely asking which matters more
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking SURMOUNT against eGFR for 19 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
Crossposting this to c/intlshipping because the people who need it are not reading this community.
the dual agonism hits different and that is why people describe it differently
the injection-site soreness from tirz is different, not necessarily worse
the 15mg is the top of the pen, not the required dose
dual agonism is Mounjaro, do not generalise from semaglutide
stalled on sema, tried tirz, and the curves were actually different shapes
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
stalled on sema, tried tirz, and the curves were actually different shapes
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Respectfully this is a sample of one presented as a finding.
the fatigue from tirz is different, not necessarily worse
the 15mg is the top of the pen, not the required dose
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
- 1stalled on sema, tried tirz, and the curves were actually different shapes7 comments in this branch · started by u/piotr_nascimento