anyone else notice SURMOUNT kicking in around week 20
Trying to settle this properly because the thread from last year went in circles.
The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 12 months without either producing anything.
What would actually settle it is 33 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Switched from sema at 7.5mg to tirz at 5mg. Different drugs, cannot compare the doses directly.
week 30 on Mounjaro and the appetite profile is genuinely different from sema
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
dual agonism is Mounjaro, do not generalise from semaglutide
Zepbound and Mounjaro are literally the same drug, the name is the only difference
the dual agonism hits different and that is why people describe it differently
the appetite change on tirz is more than just reduced hunger, it is different machinery
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Disagree on that part. 96.2% and 96.8% on the same vial is normal.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
Tracking number removed. It identifies both ends of a shipment.
week 28 on Mounjaro and the appetite profile is genuinely different from sema
Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.
Switched from sema at 5mg to tirz at 7.5mg. Different drugs, cannot compare the doses directly.
Respectfully this is a sample of one presented as a finding.
it is in the wiki actually
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
week 13 on Mounjaro and the appetite profile is genuinely different from sema
Switched from sema at 1.0mg to tirz at 12.5mg. Different drugs, cannot compare the doses directly.
the early fullness from tirz is different, not necessarily worse
week 91 on Mounjaro and the appetite profile is genuinely different from sema
week 91 on Mounjaro and the appetite profile is genuinely different from sema
Adding to this: SURPASS is doing more work than the comment implies.
The confident tone is doing a lot of work that the evidence is not.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
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Did you stay on semaglutide or switch? The outcome is different if you are comparing.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Respectfully this is a sample of one presented as a finding.
week 70 on Mounjaro and the appetite profile is genuinely different from sema
the GIP side does different things than the GLP-1 side, that is the point
- 1Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.9 comments in this branch · started by u/mikkel_ogunleye
- 2it is in the wiki actually8 comments in this branch · started by u/fatima_wojcik