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c/tirzepatide·submitted 11 months ago by u/blunt_coldbox29

anyone else notice SURMOUNT kicking in around week 20

Resultsbranch of 9 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 12 months without either producing anything. What would actually settle it is 33 people measuring the…

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9 comments, started 11 months ago
u/mikkel_ogunleye213 points·11 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/gustav_vermeulen143 points·11 months ago

dual agonism is Mounjaro, do not generalise from semaglutide

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u/quiet_moderatormod67 points·11 months ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/priya_guerrero0 points·11 months ago

the dual agonism hits different and that is why people describe it differently

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u/ferritin_low1 point·11 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/slow_logbook_ftw167 points·11 months ago·edited

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

Disagree on that part. 96.2% and 96.8% on the same vial is normal.

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u/nz_unfunded132 points·11 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/quiet_moderatorMOD122 points·11 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/sofia_nascimento100 points·11 months ago

week 28 on Mounjaro and the appetite profile is genuinely different from sema

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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