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c/tirzepatide·posted 1 year ago by u/blunt_coldbox29

anyone else notice tirzepatide kicking in around week 20

Results Clean Column ×2 Slow Clap ×1 Receipts ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything.

What would actually settle it is 11 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

5,254 up / 1,235 down81% upvoted45 commentsid of11nk5 Jul 2025

45 comments

20 in this archive, depth 4

best — the order this archive was captured in

u/quiet_moderatorMOD387 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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[deleted]253 points·1 year ago

[deleted]

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u/georgi_chowdhury80 points·1 year ago

dual agonism is GIP, do not generalise from semaglutide

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u/tarek_kirchner185 points·1 year ago·edited

Hard agree. The food noise disappears differently on the two compounds.

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u/ewan_marchand65 points·1 year ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/gustav_vermeulen59 points·1 year ago

I am going to push back on this slightly.

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u/incretin_ivypharmacology108 points·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/piotr_nascimento26 points·1 year ago

do not crack the pen, we have been over this

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u/zaid_balogun66 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/throwaway_wl202623 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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u/blunt_coldbox29OP26 points·1 year ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/dexa_twice_yearlybody comp188 points·1 year ago

Week 64 on Mounjaro and 32kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/ghrp_history225 points·1 year ago

the reflux from tirz is different, not necessarily worse

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u/copay_card_cc265 points·1 year ago

week 96 on Mounjaro and the appetite profile is genuinely different from sema

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u/priya_guerrero188 points·1 year ago·edited

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/nordic_pricing60 points·1 year ago·edited

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/throwaway_titration89 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/teodor_szabo56 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/blunt_coldbox29OP23 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/emil_wojcik54 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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