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triple agonist: what the trials say vs what this community says
Posting this because I searched for it and got nothing useful. Setup: 10mg, week 20, constipation present but not ruining anything. I changed exactly one variable —…
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long-standing contributor · joined 15 Aug 2023
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Overview — page 4 of 5
comment on dose escalation: what the trials say vs what this community says in c/retatrutide · 4 points · 1 year ago
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
comment on [Results] 86 weeks on 5mg, full numbers, ask me anything boring in c/reconstitution · 18 points · 1 year ago
dosing errors come from people reconstituting two vials differently and forgetting which is which
comment on genuine question about bacteriostatic water that I am slightly embarrassed to ask in c/reconstitution · 53 points · 1 year ago
bacteriostatic and sterile water are not interchangeable, do not use them that way
comment on 23 months in and gas fees is still the thing I get wrong in c/cryptopay · 8 points · 1 year ago
no group-buy recruitment, discussing how they fail is fine
comment on triple agonist is the most under-discussed thing in c/glp1uk in c/retatrutide · 4 points · 1 year ago
Strongly agree. Heart rate escalation needs the actual data, not impressions.
comment on [Question] New Zealand — has anyone got a straight answer on dose escalation in c/retatrutide · 51 points · 1 year ago
Mechanistically the bit that matters is TRIUMPH. It explains most of the early profile and a decent chunk of the outcome.
comment on is it normal to get constipation at week 29 in c/reconstitution · 22 points · 1 year ago
Yeah, showing the arithmetic is the fastest way for someone to spot the error.
comment on [Discussion] we are measuring USDC at the wrong time and calling it noise in c/cryptopay · 61 points · 1 year ago
Yeah, the network selection matters most.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on [Discussion] we are measuring USDC at the wrong time and calling it noise in c/cryptopay · 1 points · 1 year ago
Sent orfo payment to the wrong chain. France, wrong network, vendor could not credit it. 14 day lesson.
comment on three years of insulin syringe threads, summarised so you do not have to read them in c/reconstitution · 168 points · 1 year ago
What was the vial size and how much bac water?
comment on [Discussion] the receptor advice in here is 4 years out of date in c/glp1science · 303 points · 1 year ago
central appetite signalling is real but people overweight it
comment on [Meta] proposal — a flair for glucagon posts in c/retatrutide · 64 points · 1 year ago
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
comment on [Vendor] QST order #2 — Spain, 31 days, no drama, receipts inside in c/retatrutide · 6 points · 1 year ago
the glucagon component changes the side effect profile, not just the efficacy
comment on gastric emptying — my 18-week log, condensed into one table in c/glp1science · 67 points · 2 years ago
Yeah, the incretin mechanism is doing the work here.
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small win: mg/mL stopped being a problem at week 26
Been lurking in c/semaglutide for about 5 months and finally have something worth posting. Short version: week 20, 1.0mg, and mg/mL is the bit I still cannot get a…
comment on tried appetite for 22 weeks. here is what happened. in c/glp1science · 1 points · 2 years ago
do not extrapolate rodent data to human dosing without saying so
comment on what changed for me between week 85 and week 39 in c/reconstitution · 189 points · 2 years ago
Respectfully this is a sample of one presented as a finding.
comment on what changed for me between week 85 and week 39 in c/reconstitution · 265 points · 2 years ago
Slight fix: the number was 98.1, not 98.0. Decimal point, but a fairly consequential one.
comment on anyone else notice phase 2 kicking in around week 19 in c/retatrutide · 33 points · 2 years ago
the 10mg arm is different from 12.5mg, results do not transfer