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c/retatrutide·posted 2 years ago by u/lurker_for_years

triple agonist: what the trials say vs what this community says

Trial Data Well Actually ×5 Cold Box ×3

Posting this because I searched for it and got nothing useful.

Setup: 10mg, week 20, constipation present but not ruining anything. I changed exactly one variable — TRIUMPH — and tracked it for 10 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

1,473 up / 451 down77% upvoted28 commentsid dqy94620 Jun 2024

28 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/honest_syringe3367 points·2 years ago
i have this exact spreadsheet
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u/farid_molnar52 points·2 years ago·edited

i have this exact spreadsheet

Yes, exactly this, and it is the bit that took me 57 weeks to accept.

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u/titration_marshalmod · c/semaglutide39 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/reflux_report35 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/noor_ivaturi0 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/farid_molnar39 points·2 years ago

This is correct. Triple agonism is genuinely different.

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u/tired_ledger_notes27 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/baseline_drifteranalytical13 points·2 years ago

research use only, handling and analysis, not protocols

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u/reta_and_regretMOD24 points·2 years ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/ewan_marchand8 points·2 years ago

Flair changed to match the content.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/reta_and_regret2 points·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/farid_molnar6 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/nabila_bakken2 points·2 years ago

Slight fix: the number was 96.2, not 96.8. Decimal point, but a fairly consequential one.

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u/quiet_moderatormod5 points·2 years ago

Flair changed to match the content.

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/nabila_bakken11 points·2 years ago

nobody should be giving this to anyone without extensive monitoring

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u/careful_gradient_notes8 points·2 years ago

nobody should be giving this to anyone without extensive monitoring

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/rui_only_ro-15 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/renzo_yildiz1 point·2 years ago

triple agonism is dose escalation, do not generalise

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u/heart_rate_bump1 point·2 years ago

research use only, handling and analysis, not protocols

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u/arne_amankwah8 points·2 years ago

TRIUMPH phase 2 showed 98.0% weight loss but the fatigue profile on the highest arm was rough. Phase 2 != phase 3.

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u/ferran_krastev4 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/naomi_erdogan3 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

Yes, exactly this, and it is the bit that took me 72 weeks to accept.

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u/nikhil_asante3 points·2 years ago

phase 2 numbers are not maintenance numbers, cite the trial

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
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  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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