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c/glp1science·posted 1 year ago by u/zeynep_villalobos

[Discussion] the receptor advice in here is 4 years out of date

Discussion Cold Box ×8 Slow Clap ×1 Clean Column ×1

I have had 17 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 24 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 98.4% against a claimed 98.6%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

3,377 up / 563 down86% upvoted20 commentsid 1ww55a21 Aug 2024

20 comments

11 in this archive, depth 4

best — the order this archive was captured in

u/lurker_for_years303 points·1 year ago

central appetite signalling is real but people overweight it

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u/bastian_ekstrom70 points·1 year ago

central appetite signalling is real but people overweight it

Disagree on that part. 99.2% and 99.2% on the same vial is normal.

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u/viktor_girard-36 points·1 year ago

receptor distribution matters, GLP-1 is not everywhere

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u/rina_bergstrom1 point·1 year ago

the half-life is mechanism, affects steady state timing

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u/slow_logbook0 points·1 year ago

Respectfully this is a sample of one presented as a finding.

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u/trialwatch_theoMOD176 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/ilias_kaufmann71 points·1 year ago

rodent half-life tells you what to investigate, not what to expect in humans

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u/zeynep_villalobosOP35 points·1 year ago

Receptor distribution explains why constipation hits mechanism but not mechanism.

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u/gastric_emptying_g140 points·1 year ago

incretin physiology is half-life, the mechanism layer

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u/devils_advocate_d31 points·1 year ago

cite the paper: journal, year, first author, links optional

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u/niels_roos85 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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