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c/trialwatch·posted 1 year ago by u/hamza_zielinski

am I the only one who found SELECT harder than the injections

Press Release Cold Box ×9 Sourced ×2 Clean Column ×2

Trying to settle this properly because the thread from last year went in circles.

The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 18 months without either producing anything.

What would actually settle it is 25 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

3,473 up / 477 down88% upvoted14 commentsid yduyxc19 Dec 2024

14 comments

9 in this archive, depth 3

best — the order this archive was captured in

u/milos_vanhecke536 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/hamza_zielinskiOP253 points·1 year ago

SELECT reported a SURPASS hazard ratio but the absolute event rate is what changes clinical practice.

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u/nhs_waitlist_nUK-23 points·1 year ago

the 7 week readout is different from the 6 week readout

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u/annika_fonseca1 point·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/hamza_zielinskiOP1 point·1 year ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/marit_laurent197 points·1 year ago
this should be in the wiki
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u/trialwatch_theoMOD104 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/hamza_zielinskiOP65 points·1 year ago

STEP 1 readout: 98.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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