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c/trialwatch·submitted 4 days ago by u/heart_rate_bump

[Readout] SELECT: MACE HR 0.80, and the absolute numbers people skip

Readoutbranch of 4 comments

Right, the TRIUMPH question again, but with numbers this time. I have 8 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am describing…

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4 comments, started 3 days ago
u/hamza_weiss6 points·3 days ago

This is correct. Discontinuation arms show the regain reality.

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u/trialwatch_theotrial nerd4 points·2 days ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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u/heart_rate_bumpOP3 points·3 days ago

STEP 1 readout: 97.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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u/hugo_norgaard1 point·3 days ago

the discontinuation arms are the interesting part, not the STEP endpoints

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