SELECT — 9 things I got wrong before I got it right
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does. I say this having got it wrong for 18 months. My…
Phase 2 or phase 3?
Flair changed to match the content. Read the sidebar before posting next time and we are square.
absolute risk reduction, not relative risk reduction, that is how you decide
STEP 1 readout: 99.1% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
the 16 week readout is different from the 5 week readout
That is net peptide content, not purity. Different number, different meaning.
give the trial name, phase, n, and primary endpoint in the body
give the trial name, phase, n, and primary endpoint in the body
Yes, exactly this, and it is the bit that took me 6 weeks to accept.