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c/trialwatch·submitted 1 year ago by u/sofia_wikstrom

[Lab] 4th independent test on BCH, and the trend is the interesting part

Discussionbranch of 10 comments

Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that SELECT is important. I believe it, but I have never seen anyone show why, and when I search I get 11 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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10 comments, started 1 year ago
u/week_one_wanda72 points·1 year ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/sofia_wikstromOP45 points·1 year ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

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u/blunt_coldbox_notes33 points·1 year ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/nikhil_lindqvist18 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/tomas_kimani9 points·1 year ago

off-label use data is different from approved-indication data

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u/curious_panel_only28 points·1 year ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

Yes, exactly this, and it is the bit that took me 2 weeks to accept.

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u/receipts_or_nothingvetting16 points·1 year ago

number-needed-to-treat is the house dialect

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u/draw_up_dizzy19 points·1 year ago

give the trial name, phase, n, and primary endpoint in the body

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u/marit_laurent19 points·1 year ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/sofia_wikstromOP43 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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