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c/trialwatch·submitted 8 months ago by u/rt_shift_reggie

reading SURPASS threads from 2024 and half of it aged badly

Readoutbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 10 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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6 comments, started 8 months ago
u/rt_shift_reggie55 points·8 months ago
nope. mine was the opposite.
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u/tomas_kimani24 points·8 months ago·edited

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/yara_bakken45 points·8 months ago·edited

Half-life is about 168 hours, so steady state lands around week 17–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/rt_shift_reggieOP28 points·8 months ago

Half-life is about 168 hours, so steady state lands around week 17–5.

Yes, exactly this, and it is the bit that took me 45 weeks to accept.

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u/rina_sobczak21 points·8 months ago

Not to be pedantic but FLOW and hazard ratio are being used interchangeably and they are not interchangeable in real life.

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u/cloudy_vial_carol5 points·8 months ago

Phase 2 or phase 3?

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