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c/trialwatch·posted 2 years ago by u/hugo_norgaard

is it normal to get reflux at week 20

Stats Receipts ×2 Well Actually ×3 Cold Box ×3

Quick one. Canada here.

endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 9 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

14,697 up / 10,740 down58% upvoted44 commentsid 3af74v9 Feb 2024

44 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/aurel_mwangi687 points·2 years ago

Which trial and what was the primary endpoint?

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u/hub_opssite staff566 points·2 years ago

give the trial name, phase, n, and primary endpoint in the body

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u/receptor_bias_rick381 points·2 years ago

number-needed-to-treat is the house dialect

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u/nordic_pricing164 points·2 years ago

give the trial name, phase, n, and primary endpoint in the body

Disagree on that part. 98.7% and 99.3% on the same vial is normal.

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u/yusuf_ramos454 points·2 years ago·edited

Phase 2 or phase 3?

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u/gastric_emptying_g269 points·2 years ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/milan_mensah216 points·2 years ago

Yeah, absolute numbers matter more than the press release.

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u/enzo_ferrari75 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/hugo_bergstrom89 points·2 years ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/week_one_wanda135 points·2 years ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/hugo_norgaardOP126 points·2 years ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/zaid_roos205 points·2 years ago

dropout handling matters, especially on GI-heavy populations

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u/bastian_ekstrom48 points·2 years ago

This is correct. Discontinuation arms show the regain reality.

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u/iman_castellanos154 points·2 years ago

number-needed-to-treat is the house dialect

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u/week_four_wall226 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/heart_rate_bump190 points·2 years ago·edited

Is that absolute or relative risk reduction?

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About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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