genuine question about hazard ratio that I am slightly embarrassed to ask
FLOW. That is the whole post, but I will justify it.
Everything else people worry about in c/coa is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort FLOW out first, and almost nobody does.
I say this having got it wrong for 10 months. My A1c was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
event rates are more informative than hazard ratios alone
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
off-label use data is different from approved-indication data
Which trial and what was the primary endpoint?
dropout handling matters, especially on GI-heavy populations
Which trial and what was the primary endpoint?
This is correct. Discontinuation arms show the regain reality.
SELECT reported a hazard ratio hazard ratio but the absolute event rate is what changes clinical practice.
SELECT reported a SELECT hazard ratio but the absolute event rate is what changes clinical practice.
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
number-needed-to-treat is the house dialect
Disagree but this is the good kind of wrong — it is specific enough to be checked.
phase 2 is not phase 3, smaller n and shorter trial
Sceptical. If this were true we would see it reflected in the data and we do not.
Yeah, absolute numbers matter more than the press release.
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Respectfully this is a sample of one presented as a finding.
phase 2 is not phase 3, smaller n and shorter trial
- 1This is correct. Discontinuation arms show the regain reality.7 comments in this branch · started by u/nils_tulloch
- 2Sceptical. If this were true we would see it reflected in the data and we do…5 comments in this branch · started by u/hazard_ratio_hal