GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
Locked. A moderator closed replies on this one. It stays up because the content above the argument is worth keeping.
144
c/trialwatch·posted 1 year ago by u/rulebook_rachael

SURMOUNT: what the trials say vs what this community says

Paper

Something I noticed reading old threads that I have not seen said out loud.

The advice on SURMOUNT in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

214 up / 70 down75% upvoted9 commentsid 2gyd5l23 Jun 2025

9 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/renal_outcomes_rMOD16 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

replysharereportpermalink
u/nhs_waitlist_nUK4 points·1 year ago

This is correct. Discontinuation arms show the regain reality.

replysharereportpermalink
u/tb500_tangent4 points·1 year ago

Yeah, absolute numbers matter more than the press release.

replysharereportpermalink
u/valeria_karlsen12 points·1 year ago

Disagree. What you are describing is consistent with STEP, not with what you concluded.

replysharereportpermalink
[deleted]8 points·1 year ago

[deleted]

replysharereportpermalink
u/valeria_karlsen4 points·1 year ago

dropout handling matters, especially on GI-heavy populations

replysharereportpermalink
u/yannick_salinas2 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

replysharereportpermalink
u/first_hundred6 points·1 year ago

dropout handling matters, especially on GI-heavy populations

replysharereportpermalink
u/yara_mensah3 points·1 year ago

Phase 2 or phase 3?

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

34kmembers
95submissions
Nov 2023created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
More in c/trialwatch
c/trialwatch rules
  1. Press-release-only posts must be flaired Press Release until a publication exists.
  2. Give the trial name, phase, n, and primary endpoint in the body.
  3. Relative risk reduction alone is not a result. Show the absolute numbers.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/trialwatch_theou/forest_plot_fionau/hazard_ratio_halu/renal_outcomes_r
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →