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crossposted from c/tirzepatide by u/santiago_villalobos — GIP: what the trials say vs what this community says
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c/trialwatch·posted 1 months ago by u/yusuf_ramos

[Vendor] QST order #6 — Denmark, 5 days, no drama, receipts inside

Discussion

Trying to settle this properly because the thread from last year went in circles.

The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 9 months without either producing anything.

What would actually settle it is 33 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

61 up / 3 down96% upvoted14 commentsid 101yw318 Jun 2026

14 comments

14 in this archive, depth 5

best — the order this archive was captured in

u/alcohol_aversion13 points·1 months ago·edited

Which trial and what was the primary endpoint?

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u/sten_palacios-34 points·1 months ago

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

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u/trialwatch_theoMOD8 points·1 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/foam_head_fred5 points·1 months ago

the relative risk reduction in headlines is not the whole story

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u/niels_norgaard4 points·1 months ago·edited

phase 2 is not phase 3, smaller n and shorter trial

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u/nora_oyelaran3 points·1 months ago

phase 2 is not phase 3, smaller n and shorter trial

Disagree on that part. 99.0% and 98.9% on the same vial is normal.

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u/customs_seizure_sid3 points·1 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/milos_vanhecke1 point·1 months ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/hazard_ratio_halstats1 point·1 months ago

Yeah, absolute numbers matter more than the press release.

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u/yusuf_ramos1 point·1 months ago

the discontinuation arms are the interesting part, not the endpoint endpoints

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u/nils_tulloch1 point·1 months ago

Yeah, absolute numbers matter more than the press release.

Yes, exactly this, and it is the bit that took me 65 weeks to accept.

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u/week_four_wall1 point·1 months ago

Yeah, absolute numbers matter more than the press release.

Adding to this: TRIUMPH is doing more work than the comment implies.

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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