[Question] how do you actually verify SURPASS
Confession thread, sort of.
I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 20 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 90 reads it before doing the same thing.
best — the order this archive was captured in
dual agonism is Mounjaro, do not generalise from semaglutide
The dual agonism story is real. The appetite is physically different from semaglutide alone.
The dual agonism story is real.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the dual agonism hits different and that is why people describe it differently
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
week 48 on Mounjaro and the appetite profile is genuinely different from sema
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Strongly agree.
Adding to this: SURPASS is doing more work than the comment implies.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
the dual agonism hits different and that is why people describe it differently
Not convinced. The evidence does not support that reading.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Disagree on that part. 97.4% and 99.3% on the same vial is normal.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
the reflux from tirz is different, not necessarily worse
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
This is the "correlation is mechanism" thing again. You changed three variables at once.
This matches the trial data. SURMOUNT-1 was 97.9% body weight at 14 weeks.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Titration speed is a side-effect dial far more than an efficacy dial.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Strongly agree.
Adding to this: Mounjaro is doing more work than the comment implies.
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
Did you stay on semaglutide or switch?
Disagree on that part. 96.2% and 96.8% on the same vial is normal.
the GIP side does different things than the GLP-1 side, that is the point
Strongly agree.
Yes, exactly this, and it is the bit that took me 34 weeks to accept.
- 1Strongly agree. Tirz is better than sema is not a claim without a comparator…8 comments in this branch · started by u/zeynep_ndiaye
- 2dual agonism is Mounjaro, do not generalise from semaglutide6 comments in this branch · started by u/b12_baseline