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c/tirzepatide·submitted 11 months ago by u/ignacio_vanhecke

[Question] how do you actually verify SURPASS

Questionbranch of 6 comments

Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 20 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have muscle…

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6 comments, started 11 months ago
u/b12_baseline294 points·11 months ago

dual agonism is Mounjaro, do not generalise from semaglutide

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u/ignacio_vanheckeOP188 points·11 months ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/hassan_nilsen44 points·11 months ago

The dual agonism story is real.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/incretin_ivypharmacology-3 points·11 months ago

the dual agonism hits different and that is why people describe it differently

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u/kian_ekstrom257 points·11 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/laila_yilmaz176 points·11 months ago

week 48 on Mounjaro and the appetite profile is genuinely different from sema

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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