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c/survodutide·posted 7 months ago by u/samir_falk

dual agonist — my 21-week log, condensed into one table

Question Long Haul ×2 Slow Clap ×3

I have had 5 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 14 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 97.9% against a claimed 94.2%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

1,258 up / 80 down94% upvoted39 commentsid vr95ry6 Dec 2025

39 comments

26 in this archive, depth 6

best — the order this archive was captured in

u/tired_ledger_ftw198 points·7 months ago
i wish i had read this 12 months ago
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u/samir_falkOP131 points·7 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/endotoxin_elliemicro72 points·7 months ago

not approved, descriptive posts only

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u/teodor_szabo57 points·7 months ago

Strongly agree. The safety story is separate.

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u/rafael_sjoberg30 points·7 months ago

phase 17 data is interesting, phase 14 will be different

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u/marisol_frisk20 points·7 months ago·edited

glucagon injection is a different vector than GLP-1

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u/lina_ndiaye133 points·7 months ago
genuinely useful, thanks
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u/samir_falkOP109 points·7 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/georgi_adebayo27 points·7 months ago

My version of this: I was so worried about the injection that I put it off for eleven days.

Adding to this: biopsy is doing more work than the comment implies.

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u/patient_labslip_log38 points·7 months ago

the GLP-1/glucagon dual is glucagon, different from GIP/GLP-1

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u/mod_cold_roommod · c/coldchain9 points·7 months ago

phase 9 data is interesting, phase 32 will be different

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u/ismael_nwosu-19 points·7 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/hana_pereira1 point·7 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/throwaway_wl20261 point·7 months ago

Half-life is about 168 hours, so steady state lands around week 2–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/sofia_ferreira1 point·7 months ago

glucagon injection is a different vector than GLP-1

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u/whois_wanda65 points·7 months ago

Not convinced. The evidence does not support that reading.

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u/elin_tamm44 points·7 months ago

glucagon co-agonism has a different safety story

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u/teodor_szabo18 points·7 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/diego_szabo9 points·7 months ago

the safety profile is not just tirzepatide amplified

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u/chidi_demir17 points·7 months ago

the heart rate signal is real in the data

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u/neha_rahimi5 points·7 months ago·edited

the heart rate signal is real in the data

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/zeynep_ndiaye4 points·7 months ago

Strongly agree. The safety story is separate.

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u/nora_ramos1 point·7 months ago

phase 22 data is interesting, phase 16 will be different

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u/samir_falkOP25 points·7 months ago

Not convinced.

Disagree on that part. 99.2% and 98.9% on the same vial is normal.

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u/sofia_ferreira17 points·7 months ago

Respectfully this is a sample of one presented as a finding.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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