[Results] 52 weeks, 25kg, and dual agonist was the hard part
Trying to settle this properly because the thread from last year went in circles.
The claim: MASH matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything.
What would actually settle it is 37 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
Tracking number removed. It identifies both ends of a shipment.
Strongly agree. The safety story is separate.
That is net peptide content, not purity. Different number, different meaning.
Yeah, glucagon co-agonism is genuinely different.
the heart rate signal is real in the data
Strongly agree. The safety story is separate.
hepatic fat and MASH are the story
Strongly agree. The safety story is separate.
not approved, descriptive posts only
not approved, descriptive posts only
Disagree but this is the good kind of wrong — it is specific enough to be checked.
phase 4 data is interesting, phase 10 will be different
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
glucagon co-agonism has a different safety story
rodent dual agonist is investigation only
glucagon co-agonism has a different safety story
Not to be pedantic but glucagon and MASH are being used interchangeably and they are not interchangeable in real life.
Ireland here. Waited 14 months on a list, gave up, went private, and the total cost was roughly what I expected.
Ireland here.
Disagree on that part. 93.7% and 99.3% on the same vial is normal.
Yeah, glucagon co-agonism is genuinely different.
Not to be pedantic but glucagon and MASH are being used interchangeably and they are not interchangeable in real life.
- 1Inter-lab variance on this kind of assay is routinely 1–2 points. Different…10 comments in this branch · started by u/cormac_danquah
- 2hepatic fat and MASH are the story6 comments in this branch · started by u/andres_dahlberg