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c/semaglutide·posted 8 months ago by u/camila_sandvik

weekly dosing is the most under-discussed thing in c/labresults

Results Cold Box ×8 Slow Clap ×1 Clean Column ×1

Confession thread, sort of.

I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 16 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 81 reads it before doing the same thing.

4,138 up / 614 down87% upvoted56 commentsid g6tw2p15 Nov 2025

56 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/kaplan_meier_kim267 points·8 months ago

Did anything else change in the same window? Sleep, protein, steps, anything?

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u/niels_lindqvist147 points·8 months ago

pens are overpriced, research vials are research grade, same molecule different price

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[removed]100 points·8 months ago

[removed by moderator]

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u/careful_gradient_again329 points·8 months ago·edited

Did anything else change in the same window?

Adding to this: Ozempic is doing more work than the comment implies.

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u/camila_sandvikOP126 points·8 months ago

I am going to push back on this slightly.

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u/katrin_diallo118 points·8 months ago·edited

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/joaquin_stanescu-31 points·8 months ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/rania_diallo1 point·8 months ago·edited

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/camila_sandvikOP1 point·8 months ago

Sweden here. Waited 4 months on an NHS list, gave up, went private, and the cost was half what I expected but the admin was worse.

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u/oskar_ibarra123 points·8 months ago

You have restated the marketing copy. What is the actual substance here.

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u/titration_marshalMOD83 points·8 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/units_not_mgsyringe math29 points·8 months ago

titration speed is weekly dosing plus side effects, period

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u/test_it_yourselfvetting60 points·8 months ago

my ALT moved before the scale did and i nearly missed it

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u/hugo_bergstrom38 points·8 months ago

week 89 on the pen, 25kg down, this is the answer

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u/kenji_vasquez37 points·8 months ago·edited

You have restated the marketing copy.

Disagree on that part. 98.1% and 97.6% on the same vial is normal.

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u/runa_wikstrom12 points·8 months ago

Small correction: the trial was 2 weeks, not 20. Does not change your point but people will quote it.

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u/oskar_ibarra79 points·8 months ago

Lost 22kg and gained a genuinely irritating amount of interest in analytical chemistry. This site did that to me.

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u/kaplan_meier_kim43 points·8 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/units_not_mgsyringe math26 points·8 months ago

okay but what dose of sema are you on

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u/test_it_yourselfvetting12 points·8 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/rohan_steiner46 points·8 months ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/camila_sandvikOP60 points·8 months ago

nope, 0.25 counts, it is just not the dose most people stay on

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u/zofia_lindholm92 points·8 months ago

okay but what dose of sema are you on

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u/archived_thread_a27 points·8 months ago·edited

okay but what dose of sema are you on

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/aleksi_grimaldi17 points·8 months ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/rafael_ostergaard96 points·8 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/ahmed_okafor39 points·8 months ago

pens are overpriced, research vials are research grade, same molecule different price

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u/ravi_bergstrom29 points·8 months ago

Sceptical.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/sorted_by_new20 points·8 months ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/nikhil_teixeira57 points·8 months ago

nope, 0.25 counts, it is just not the dose most people stay on

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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