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c/semaglutide·posted 1 year ago by u/adnan_karlsen

[Results] 67 weeks, 36kg, and plateau was the hard part

Results Sourced ×9 Long Haul ×2 Clean Column ×2

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking semaglutide against eGFR for 3 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

9,598 up / 369 down96% upvoted37 commentsid 1c3bo83 May 2025

37 comments

20 in this archive, depth 5

best — the order this archive was captured in

u/hamza_weiss1.8k points·1 year ago

Stalled at 0.25mg, changed nothing, and it started moving again on week 25. Very nearly went up. Glad I did not.

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u/units_not_mgMOD1.1k points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/adnan_karlsenOP-26 points·1 year ago

Week 39 for me and the honest summary is: 9kg down, sulphur burps manageable, and the quiet happened around week 24.

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u/adnan_karlsenOP1.1k points·1 year ago

Yeah, 44 weeks on 1.7mg, same pattern, same timing.

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u/bilal_osei1.3k points·1 year ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/adnan_karlsenOP733 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/diego_sorensen660 points·1 year ago

Week 49 for me and the honest summary is: 35kg down, fatigue manageable, and the quiet happened around week 18.

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u/nikhil_teixeira407 points·1 year ago

titration speed is weekly dosing plus side effects, period

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u/vikram_ferreira202 points·1 year ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/anya_salgado63 points·1 year ago

week 71 on the pen, 29kg down, this is the answer

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u/archived_thread_a72 points·1 year ago

week 65 and i am still not at maintenance, do not rush the ladder

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u/nausea_notesside effects303 points·1 year ago

Did you time the injection consistently each week or was it more ad hoc?

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u/wanjiru_varga248 points·1 year ago

Hard agree. Week 77 me needed this. Week 25 me is nodding smugly.

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u/endpoint_creep60 points·1 year ago

Cosigning. The slow route gets the outcome, the fast route gets you the side effects.

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u/noor_hovland128 points·1 year ago·edited

week 80 and i am still not at maintenance, do not rush the ladder

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[deleted]246 points·1 year ago

[deleted]

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u/units_not_mgsyringe math455 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/teodor_duarte207 points·1 year ago

titration speed is food noise plus side effects, period

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u/ewan_tulloch88 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/ines_castellanos252 points·1 year ago

my eGFR moved before the scale did and i nearly missed it

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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