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c/retatrutide·posted 6 months ago by u/injection_site_iris

[Lab] 16th independent test on QSC, and the trend is the interesting part

Lab Long Haul ×2 Cold Box ×3 Clean Column ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking retatrutide against triglycerides for 25 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

5,809 up / 348 down94% upvoted51 commentsid vwyz5827 Jan 2026

51 comments

16 in this archive, depth 3

best — the order this archive was captured in

u/trialwatch_theoMOD709 points·6 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/nordic_pricing220 points·6 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/farid_molnar154 points·6 months ago

Are you quoting phase 2 or is there phase 3 data now?

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u/yusuf_ramos555 points·6 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/marit_laurent374 points·6 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/cormac_roos570 points·6 months ago·edited

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/andres_restrepo88 points·6 months ago

Did you actually measure heart rate or is that a feeling?

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u/injection_site_irisOP318 points·6 months ago

research use only, handling and analysis, not protocols

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u/heart_rate_bump456 points·6 months ago

Which trial arm and what was the n?

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u/farid_molnar368 points·6 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/reta_and_regret193 points·6 months ago

Which trial arm and what was the n?

Yes, exactly this, and it is the bit that took me 12 weeks to accept.

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u/andres_sorensen56 points·6 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/nadia_norgaard274 points·6 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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[deleted]190 points·6 months ago

[deleted]

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u/incretin_ivypharmacology157 points·6 months ago

[deleted]

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/injection_site_irisOP124 points·6 months ago

the glucagon component changes the side effect profile, not just the efficacy

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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