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c/retatrutide·posted 5 months ago by u/careful_gradient32

week 16 check-in — 42kg down, constipation manageable, one thing confusing me

Discussion Slow Clap ×5 Receipts ×1

Been lurking in c/sideeffects for about 17 months and finally have something worth posting.

Short version: week 36, 5mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 13 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 42.

1,763 up / 284 down86% upvoted32 commentsid vcwm9b22 Feb 2026

32 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/incretin_ivypharmacology246 points·5 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/employer_carveout85 points·5 months ago

nobody should be giving this to anyone without extensive monitoring

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u/deleted_my_history47 points·5 months ago

the 1.7mg arm is different from 2.4mg, results do not transfer

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u/bastian_ekstrom34 points·5 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/reflux_report28 points·5 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/heart_rate_bump125 points·5 months ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/yusuf_ramos114 points·5 months ago

This is correct. Triple agonism is genuinely different.

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u/incretin_ivyMOD64 points·5 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/rohan_cardoso53 points·5 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/andres_restrepo0 points·5 months ago

Not to be pedantic but triple agonist and glucagon are being used interchangeably and they are not interchangeable in real life.

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u/discount_math_dm-7 points·5 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/careful_gradient_notes76 points·5 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/ledger_modmod · vetting23 points·5 months ago·edited

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/mod_cold_roommod · c/coldchain5 points·5 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/careful_gradient32OP0 points·5 months ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/marit_laurent61 points·5 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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