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c/retatrutide·posted 5 months ago by u/burned_once_twice

[Vendor] WXT order #4 — Germany, 13 days, no drama, receipts inside

Caution Clean Column ×6

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking retatrutide against eGFR for 27 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

4,344 up / 3,826 down53% upvoted20 commentsid v2x0kc28 Feb 2026

20 comments

12 in this archive, depth 5

best — the order this archive was captured in

u/mateusz_mensah-24 points·5 months ago

Did you actually measure heart rate or is that a feeling?

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u/marit_laurent1 point·5 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/burned_once_twiceOP1 point·5 months ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/marta_vanhecke1 point·5 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/nikhil_lindqvist1 point·5 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/careful_gradient_notes1 point·5 months ago·edited

triple agonism is retatrutide, do not generalise

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[removed]1 point·5 months ago

[removed by moderator]

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u/andres_restrepo71 points·5 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/nikhil_lindqvist88 points·5 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/renzo_yildiz30 points·5 months ago·edited

heart rate and dose escalation need actual measurements, not impressions

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u/tired_ledger_notes10 points·5 months ago

This is correct. Triple agonism is genuinely different.

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u/incretin_ivyMOD55 points·4 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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