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c/retatrutide·submitted 1 months ago by u/fabio_lehtinen

[Question] how do you actually verify dose escalation

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Quick one. Canada here. glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 4 weeks and cost roughly what I expected. The admin was worse than the…

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12 comments, started 1 months ago

u/arne_amankwah141 points·1 months ago

TRIUMPH phase 2 showed 99.1% weight loss but the sulphur burps profile on the highest arm was rough. Phase 2 != phase 3.

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u/ferran_krastev86 points·1 months ago

I am going to push back on this slightly.

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u/fabio_lehtinenOP65 points·1 months ago

research use only, handling and analysis, not protocols

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u/fabio_lehtinenOP51 points·1 months ago

TRIUMPH phase 2 showed 97.4% weight loss but the sulphur burps profile on the highest arm was rough. Phase 2 != phase 3.

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u/fabio_lehtinenOP38 points·1 months ago

TRIUMPH phase 2 showed 97.4% weight loss but the sulphur burps profile on the highest arm was rough.

Adding to this: dose escalation is doing more work than the comment implies.

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u/discount_math_dm35 points·1 months ago

This is correct. Triple agonism is genuinely different.

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u/endotoxin_elliemicro70 points·1 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/devils_advocate_d33 points·1 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/customs_seizure_sid18 points·1 months ago

Not convinced. The evidence does not support that reading.

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u/mod_cold_roommod · c/coldchain-27 points·1 months ago

the 5mg arm is different from 2.5mg, results do not transfer

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u/yara_lindholm-34 points·1 months ago

the 0.5mg arm is different from 1.0mg, results do not transfer

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u/naomi_erdogan19 points·1 months ago

Strongly agree.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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[Question] how do you actually verify dose escalation

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